Literature summary extracted from

Lu, C.Y.; Hsieh, S.Y.; Lu, Y.J.; Wu, C.S.; Chen, L.C.; Lo, S.J.; Wu, C.T.; Chou, M.Y.; Huang, T.H.; Chang, Y.S.
Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma (2009), Genes Chromosomes Cancer, 48, 1057-1068.

Application

EC Number	Application	Comment	Organism
3.4.21.B41	diagnostics	hypermethylated KLK10 is frequent in hepatocellular carcinoma and may be useful as marker for clinical application	Homo sapiens

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
3.4.21.B41	gene KLK10, located at 19q13.3-q13.4, quantitative real-time PCR expression analysis, determination of DNA hypermethylation status of KLK10 in hepatocellular carcinoma cell lines and clinical samples, DNA methylation profiles, overview. Ectopic expression of KLK10 enhances drug sensitivity of HuH7 cells	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.21.B41	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.21.B41	Hep-G2 cell	-	Homo sapiens	-
3.4.21.B41	hepatocellular carcinoma cell	hypermethylated KLK10 is frequent in hepatocellular carcinoma	Homo sapiens	-
3.4.21.B41	Huh-7 cell	-	Homo sapiens	-
3.4.21.B41	J7 hepatoma cell	-	Homo sapiens	-
3.4.21.B41	Mahlavu cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.21.B41	kallikrein-related peptidase 10	-	Homo sapiens
3.4.21.B41	KLK10	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.21.B41	malfunction	KLK10 hypermethylation is significantly associated with cirrhosis and HCV infection as well as inversely associated with HBV infection. Restoration of KLK10 expression, by 5-aza-cytidine treatment, reduces the ability of anchorage-independent growth, and sensitizes hepatocellular carcinoma cells to doxorubicin- or 5-fluorouracil-induced cytotoxicity	Homo sapiens

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Release 2023.1 (January 2023)